To reconstruct Aβ production in mouse embryonic fibroblasts, wild-kind or mutant Aph1-aL cDNAs had been inserted in the Eco
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This examine uncovered that Aph1aL may be actively associated with γ-secretase catalytic action. We analyzed the manufacture of distinctive Aβ species and located that the ratio of long Aβ species (Aβ42 and Aβ43) that has aβ40 was identical concerning the Aph1aL WT and L30F/T164A double mutant.
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